This article has considered a topic that is currently considered very relevant. The topic of the article is the development of students' critical thinking skills through interactive learning strategies in the study of natural sciences and mathematics. Why is this topic relevant? The article examines the experience of organizing the Lesson Study approach and substantiates the effectiveness of its application, since the study of the lesson is aimed at the professional development of the teacher, his training and support. A tendency to change the approach to learning has been identified, which makes it possible to improve teaching methods and helps to increase the level of knowledge of each student. Therefore, it is important to increase students' interest in natural science subjects. The article provides data on the benefits for humanity of natural science subjects – chemistry, geography, biology, mathematics. In particular, the household items that we use today, the food industry, laundry, medicines that we use, and much more are directly related to natural disciplines. Therefore, natural sciences are considered a very useful science for mankind. The article also identified the reasons for the low interest of students in natural sciences, in the Literature Review section, studies conducted by chemistry scientists during lessons for schoolchildren, technologies and teaching methods that increase the interest of schoolchildren in chemistry are considered. In the research methods as a whole, work was done on the basis of general data based on all the facts and their own experience. "Why are science subjects a problem for students, how can we get students interested in science subjects"? Answers to these questions have been found and research has been conducted to increase students' interest in natural subjects. In research methods, an experiment was conducted on how much they help students develop critical thinking skills when teaching science and mathematics through interactive learning strategies. Students adapted to this standard will definitely be able to understand natural sciences and mathematics, and their interests will increase. Studies of students have revealed the reasons for the low level of knowledge and interest of students in natural subjects.