The article discusses a laboratory model experiment on cleaning soil contaminated with oil and petroleum products using active associations based on oil-oxidizing bacteria-destructors. Oil and petroleum products are among the most common pollutants of the biosphere. The problem of cleaning the environment from oil pollution is becoming increasingly acute due to the limited possibilities (more precisely, environmental harm) of using mechanical and physico-chemical cleaning methods for these purposes. In this regard, recently the biological method of cleaning up oil pollution has attracted more and more attention from scientists. A laboratory model experiment was carried out with active associations: Association I (Rhodococcus sp. 1D/1, Tessaracoccus sp. 13/8, Dietzia sp. 13/4) and Association II (Gordonia sp. 12/5, Dietzia sp. 12/7, Rhodococcus erythropolis 14/1, Arthrobacter sp. 15/3) and joint application of organomineral fertilizers (NPK + manure) with these associations. The results of the experiment showed that the application of organo-mineral fertilizers with active associations based on oil-oxidizing bacteria has an effective effect on cleaning the soil from oil and oil products. During a laboratory experiment, Association II showed high results in the destruction of oil and petroleum products with and without the use of organomineral fertilizers.